This is not if it asks for a new Serial Number, but if Inventor gives a white pop-up saying it cannot find licensing components.
This can be caused by different patch levels, so there are different Autodesk Master License packages available.
Fix
Try a different release of the Autodesk Master License package.
Open up Cloud Paging Player and remove the Autodesk Master License package.
Go to the AppsAnywhere Web UI.
Select v5Nrel3 on the dropdown menu. This is the latest version.
If that doesn't work, remove the Autodesk Master License package again from Cloud Paging Player.
Try the Nrel4 option.
If this still doesn't work, repeat steps 4 and 5 trying different patches. (rel11, rel9, and rel10)